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Rational Selection of CRISPR-Cas9 Guide RNAs for Homology-Directed Genome Editing
Homology-directed repair (HDR) of a DNA break allows copying of genetic material from an exogenous DNA template and is frequently exploited in CRISPR-Cas9 genome editing. However, HDR is in competition with other DNA repair pathways, including non-homologous end joining (NHEJ) and microhomology-medi...
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| Publicado no: | Mol Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7934447/ https://ncbi.nlm.nih.gov/pubmed/33160457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.006 |
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