Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9

Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility, and cancers. The lack of cellular and animal models for chromosomal translocations, however, has hampered our ability to understand the underlying dise...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jiang, Junfeng, Zhang, Li, Zhou, Xingliang, Chen, Xi, Huang, Guanyi, Li, Fengsheng, Wang, Ruizhe, Wu, Nancy, Yan, Youzhen, Tong, Chang, Srivastava, Sankalp, Wang, Yue, Liu, Houqi, Ying, Qi-Long
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761995/
https://ncbi.nlm.nih.gov/pubmed/26898344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21918
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