Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9

Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility, and cancers. The lack of cellular and animal models for chromosomal translocations, however, has hampered our ability to understand the underlying dise...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Jiang, Junfeng, Zhang, Li, Zhou, Xingliang, Chen, Xi, Huang, Guanyi, Li, Fengsheng, Wang, Ruizhe, Wu, Nancy, Yan, Youzhen, Tong, Chang, Srivastava, Sankalp, Wang, Yue, Liu, Houqi, Ying, Qi-Long
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761995/
https://ncbi.nlm.nih.gov/pubmed/26898344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21918
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