Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9

Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility, and cancers. The lack of cellular and animal models for chromosomal translocations, however, has hampered our ability to understand the underlying dise...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Jiang, Junfeng, Zhang, Li, Zhou, Xingliang, Chen, Xi, Huang, Guanyi, Li, Fengsheng, Wang, Ruizhe, Wu, Nancy, Yan, Youzhen, Tong, Chang, Srivastava, Sankalp, Wang, Yue, Liu, Houqi, Ying, Qi-Long
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761995/
https://ncbi.nlm.nih.gov/pubmed/26898344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21918
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