LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency

Human DNA ligase I (LIG1) is the main replicative ligase and it also seals DNA breaks to complete DNA repair and recombination pathways. Immune compromised patients harbor hypomorphic LIG1 alleles encoding substitutions of conserved arginine residues, R771W and R641L, that compromise LIG1 activity t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jurkiw, Thomas J, Tumbale, Percy P, Schellenberg, Matthew J, Cunningham-Rundles, Charlotte, Williams, R Scott, O’Brien, Patrick J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897520/
https://ncbi.nlm.nih.gov/pubmed/33444456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1297
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