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LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency
Human DNA ligase I (LIG1) is the main replicative ligase and it also seals DNA breaks to complete DNA repair and recombination pathways. Immune compromised patients harbor hypomorphic LIG1 alleles encoding substitutions of conserved arginine residues, R771W and R641L, that compromise LIG1 activity t...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7897520/ https://ncbi.nlm.nih.gov/pubmed/33444456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1297 |
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