The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigenic variation. RAD50, a component of the MRN complex (MRE11, RAD50, NBS1), is central to homologous re...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Mehnert, Ann-Kathrin, Prorocic, Marco, Dujeancourt-Henry, Annick, Hutchinson, Sebastian, McCulloch, Richard, Glover, Lucy
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897489/
https://ncbi.nlm.nih.gov/pubmed/33450001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1265
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