The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigenic variation. RAD50, a component of the MRN complex (MRE11, RAD50, NBS1), is central to homologous re...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Mehnert, Ann-Kathrin, Prorocic, Marco, Dujeancourt-Henry, Annick, Hutchinson, Sebastian, McCulloch, Richard, Glover, Lucy
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897489/
https://ncbi.nlm.nih.gov/pubmed/33450001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1265
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