The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigenic variation. RAD50, a component of the MRN complex (MRE11, RAD50, NBS1), is central to homologous re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Mehnert, Ann-Kathrin, Prorocic, Marco, Dujeancourt-Henry, Annick, Hutchinson, Sebastian, McCulloch, Richard, Glover, Lucy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2021
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897489/
https://ncbi.nlm.nih.gov/pubmed/33450001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1265
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