Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

Active DNA demethylation via Ten-eleven Translocation (TET) family enzymes is essential for epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three successive oxidations of 5-methylcytosine (5mC), generating 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), or 5-ca...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Caldwell, Blake A., Liu, Monica Yun, Prasasya, Rexxi D., Wang, Tong, DeNizio, Jamie E., Leu, N. Adrian, Amoh, Nana Yaa A., Krapp, Christopher, Lan, Yemin, Shields, Emily J., Bonasio, Roberto, Lengner, Christopher J., Kohli, Rahul M., Bartolomei, Marisa S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897302/
https://ncbi.nlm.nih.gov/pubmed/33352108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.045
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