Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells

BACKGROUND: The G1 checkpoint is a critical regulator of genomic stability in untransformed cells, preventing cell cycle progression after DNA damage. DNA double-strand breaks (DSBs) recruit and activate ATM, a kinase which in turn activates the CHK2 kinase to establish G1 arrest. While the onset of...

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Pubblicato in:BMC Biol
Autori principali: García-Santisteban, Iraia, Llopis, Alba, Krenning, Lenno, Vallejo-Rodríguez, Jon, van den Broek, Bram, Zubiaga, Ana M., Medema, René H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896382/
https://ncbi.nlm.nih.gov/pubmed/33607997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-00965-x
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