Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1

Activation of the DNA-damage checkpoint culminates in the inhibition of cyclin-dependent kinase (Cdk) complexes to prevent cell-cycle progression. We have shown recently that Cdk activity is required for activation of the Forkhead transcription factor FoxM1, an important regulator of gene expression...

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Detalhes bibliográficos
Main Authors: Alvarez-Fernández, Mónica, Halim, Vincentius A, Krenning, Lenno, Aprelia, Melinda, Mohammed, Shabaz, Heck, Albert J, Medema, René H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892325/
https://ncbi.nlm.nih.gov/pubmed/20379221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.46
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