Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation

The forkhead transcription factor FoxM1 controls expression of a large number of genes that are specifically expressed during the G(2) phase of the cell cycle. Throughout most of the cell cycle, FoxM1 activity is restrained by an autoinhibitory mechanism, involving a repressor domain present in the...

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Detalhes bibliográficos
Main Authors: Alvarez-Fernández, Mónica, Halim, Vincentius A., Aprelia, Melinda, Mohammed, Shabaz, Medema, René H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190881/
https://ncbi.nlm.nih.gov/pubmed/21813648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253724
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