Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

The basic machinery that detects DNA damage is the same throughout the cell cycle. Here, we show, in contrast, that reversal of DNA damage responses (DDRs) and recovery are fundamentally different in G1 and G2 phases of the cell cycle. We find that distinct phosphatases are required to counteract th...

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Autori principali: Shaltiel, Indra A., Aprelia, Melinda, Saurin, Adrian T., Chowdhury, Dipanjan, Kops, Geert J. P. L., Voest, Emile E., Medema, René H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034242/
https://ncbi.nlm.nih.gov/pubmed/24711418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322021111
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