Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here we report that loss of ALC1 confers sensitivity to PARP i...

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Publicado en:Mol Cell
Main Authors: Hewitt, Graeme, Borel, Valerie, Segura-Bayona, Sandra, Takaki, Tohru, Ruis, Phil, Bellelli, Roberto, Lehmann, Laura C., Sommerova, Lucia, Vancevska, Aleksandra, Tomas-Loba, Antonia, Zhu, Kang, Cooper, Christopher, Fugger, Kasper, Patel, Harshil, Goldstone, Robert, Schneider-Luftman, Deborah, Herbert, Ellie, Stamp, Gordon, Brough, Rachel, Pettitt, Stephen, Lord, Christopher J., West, Stephen C., Ahel, Ivan, Ahel, Dragana, Chapman, J. Ross, Deindl, Sebastian, Boulton, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895907/
https://ncbi.nlm.nih.gov/pubmed/33333017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.006
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