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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Polo-Like Kinase (Plk2) alters the Ratio of Its GAP Activity toward HRas, Rap1 and Rap2 GTPases
SynGAP is a Ras and Rap GTPase-activating protein (GAP) found in high concentration in the postsynaptic density (PSD) fraction from mammalian forebrain where it binds to PDZ domains of PSD-95. Phosphorylation of pure recombinant synGAP by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) shifts...
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| Publicado en: | Biochem Biophys Res Commun |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894274/ https://ncbi.nlm.nih.gov/pubmed/30049443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.07.087 |
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