The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

The brain-specific synaptic guanosine triphosphatase (GTPase)-activating protein (SynGAP) is important in synaptic plasticity. It shows dual specificity for the small guanine nucleotide-binding proteins Rap and Ras. Here, we show that RapGAP activity of SynGAP requires its C2 domain. In contrast to...

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Detalhes bibliográficos
Main Authors: Pena, Vladimir, Hothorn, Michael, Eberth, Alexander, Kaschau, Nikolai, Parret, Annabel, Gremer, Lothar, Bonneau, Fabien, Ahmadian, Mohammad Reza, Scheffzek, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288765/
https://ncbi.nlm.nih.gov/pubmed/18323856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.20
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