Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Polo-Like Kinase (Plk2) alters the Ratio of Its GAP Activity toward HRas, Rap1 and Rap2 GTPases

SynGAP is a Ras and Rap GTPase-activating protein (GAP) found in high concentration in the postsynaptic density (PSD) fraction from mammalian forebrain where it binds to PDZ domains of PSD-95. Phosphorylation of pure recombinant synGAP by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) shifts...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Walkup, Ward G., Sweredoski, Michael J., Graham, Robert L., Hess, Sonja, Kennedy, Mary B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894274/
https://ncbi.nlm.nih.gov/pubmed/30049443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.07.087
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