Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the mammalian forebrain. We have previously shown that, in situ in the PSD fraction or in recombinant form in Sf9 cell membranes, synGAP is phosphoryla...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Walkup, Ward G., Washburn, Lorraine, Sweredoski, Michael J., Carlisle, Holly J., Graham, Robert L., Hess, Sonja, Kennedy, Mary B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335230/
https://ncbi.nlm.nih.gov/pubmed/25533468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614420
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