Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the mammalian forebrain. We have previously shown that, in situ in the PSD fraction or in recombinant form in Sf9 cell membranes, synGAP is phosphoryla...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Walkup, Ward G., Washburn, Lorraine, Sweredoski, Michael J., Carlisle, Holly J., Graham, Robert L., Hess, Sonja, Kennedy, Mary B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Neurobiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335230/
https://ncbi.nlm.nih.gov/pubmed/25533468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614420
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