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LETROZOLE TARGETS THE HUMAN ETHER-A-GO-GO-RELATED GENE (HERG) POTASSIUM CURRENT IN GLIOBLASTOMA

Aberrant expression of human ether-a-go-go-related gene (hERG) potassium channels has been implicated in the pathophysiology of glioblastoma (GBM). Letrozole has demonstrated efficacy in pre-clinical GBM models. The objective of this research was to assess the potential for hERG inhibition by letroz...

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Publicado en:Basic Clin Pharmacol Toxicol
Autores principales: Shugg, Tyler, Dave, Nimita, Amarh, Enoch, Assiri, Abdullah A., Pollok, Karen E., Overholser, Brian R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889647/
https://ncbi.nlm.nih.gov/pubmed/33040444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.13515
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