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Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states
1. Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity blockade of I(Kr) (encoded by HERG). 2. In a chronic transfection model using CHO-K1 cells, cisapride inhibited HE...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571630/ https://ncbi.nlm.nih.gov/pubmed/10510456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702774 |
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