Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states

1. Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity blockade of I(Kr) (encoded by HERG). 2. In a chronic transfection model using CHO-K1 cells, cisapride inhibited HE...

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Bibliographic Details
Main Authors: Walker, B D, Singleton, C B, Bursill, J A, Wyse, K R, Valenzuela, S M, Qiu, M R, Breit, S N, Campbell, T J
Format: Artigo
Language:Inglês
Published: 1999
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571630/
https://ncbi.nlm.nih.gov/pubmed/10510456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702774
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