Caricamento...

Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states

1. Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity blockade of I(Kr) (encoded by HERG). 2. In a chronic transfection model using CHO-K1 cells, cisapride inhibited HE...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Walker, B D, Singleton, C B, Bursill, J A, Wyse, K R, Valenzuela, S M, Qiu, M R, Breit, S N, Campbell, T J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571630/
https://ncbi.nlm.nih.gov/pubmed/10510456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702774
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !