Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleate

1. Perhexiline has been used as an anti-anginal agent for over 25 years, and is known to cause QT prolongation and torsades de pointes. We hypothesized that the cellular basis for these effects was blockade of I(Kr). 2. A stable transfection of HERG into a CHO-K1 cell line produced a delayed rectifi...

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Detalhes bibliográficos
Main Authors: Walker, B D, Valenzuela, S M, Singleton, C B, Tie, H, Bursill, J A, Wyse, K R, Qiu, M R, Breit, S N, Campbell, T J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565989/
https://ncbi.nlm.nih.gov/pubmed/10369479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702502
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