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Inhibition of HERG potassium channels by the antimalarial agent halofantrine

1. Halofantrine is a widely used antimalarial agent which has been associated with prolongation of the ‘QT interval' of the electrocardiogram (ECG), torsades de pointes and sudden death. Whilst QT prolongation is consistent with halofantrine-induced increases in cardiac ventricular action poten...

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Detalhes bibliográficos
Main Authors: Tie, H, Walker, B D, Singleton, C B, Valenzuela, S M, Bursill, J A, Wyse, K R, Breit, S N, Campbell, T J
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572249/
https://ncbi.nlm.nih.gov/pubmed/10952689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703470
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