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LETROZOLE TARGETS THE HUMAN ETHER-A-GO-GO-RELATED GENE (HERG) POTASSIUM CURRENT IN GLIOBLASTOMA
Aberrant expression of human ether-a-go-go-related gene (hERG) potassium channels has been implicated in the pathophysiology of glioblastoma (GBM). Letrozole has demonstrated efficacy in pre-clinical GBM models. The objective of this research was to assess the potential for hERG inhibition by letroz...
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| Publicado no: | Basic Clin Pharmacol Toxicol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7889647/ https://ncbi.nlm.nih.gov/pubmed/33040444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.13515 |
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