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Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats

Thromboxane A2 (TXA(2)) promotes various physiological responses including pulmonary artery (PA) contraction, and pathophysiological implications have been suggested in cardiovascular diseases including pulmonary hypertension. Here, we investigated the role of TXA(2) receptor (TP)-mediated signaling...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Cho, Suhan, Namgoong, Hyun, Kim, Hae Jin, Vorn, Rany, Yoo, Hae Young, Kim, Sung Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886809/
https://ncbi.nlm.nih.gov/pubmed/33613315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.624967
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