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Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats
Thromboxane A2 (TXA(2)) promotes various physiological responses including pulmonary artery (PA) contraction, and pathophysiological implications have been suggested in cardiovascular diseases including pulmonary hypertension. Here, we investigated the role of TXA(2) receptor (TP)-mediated signaling...
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| Pubblicato in: | Front Physiol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7886809/ https://ncbi.nlm.nih.gov/pubmed/33613315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.624967 |
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