Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib‐Induced Hypertension

BACKGROUND: The tyrosine kinase inhibitor sunitinib causes hypertension associated with reduced nitric oxide (NO) availability, elevated renal vascular resistance, and decreased fractional sodium excretion. We tested whether (1) nitrate supplementation mitigates sunitinib‐induced hypertension and NO...

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Pubblicato in:J Am Heart Assoc
Autori principali: Witte, Jeannine, Mühlbauer, Melanie, Braun, Diana, Steinbach, Antje, Golchert, Janine, Rettig, Rainer, Grisk, Olaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222942/
https://ncbi.nlm.nih.gov/pubmed/30371202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009557
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