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Renal Soluble Guanylate Cyclase Is Downregulated in Sunitinib‐Induced Hypertension

BACKGROUND: The tyrosine kinase inhibitor sunitinib causes hypertension associated with reduced nitric oxide (NO) availability, elevated renal vascular resistance, and decreased fractional sodium excretion. We tested whether (1) nitrate supplementation mitigates sunitinib‐induced hypertension and NO...

詳細記述

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書誌詳細
出版年:J Am Heart Assoc
主要な著者: Witte, Jeannine, Mühlbauer, Melanie, Braun, Diana, Steinbach, Antje, Golchert, Janine, Rettig, Rainer, Grisk, Olaf
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222942/
https://ncbi.nlm.nih.gov/pubmed/30371202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009557
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