Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets

Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and facilitate intercellular trafficking of molecules. In this study, we report the expression and function of an orphan connexin, connexin-62 (Cx62), in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sahli, Khaled A., Flora, Gagan D., Sasikumar, Parvathy, Maghrabi, Ali H., Holbrook, Lisa-Marie, AlOuda, Sarah K., Elgheznawy, Amro, Sage, Tanya, Stainer, Alexander R., Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vaiyapuri, Sakthivel, Bye, Alexander P., Unsworth, Amanda J., Jones, Chris I., McGuffin, Liam J., Gibbins, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885822/
https://ncbi.nlm.nih.gov/pubmed/32822477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004575
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