Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

por Unsworth, Amanda J., Bye, Alexander P., Kriek, Neline, Sage, Tanya, Osborne, Ashley A., Donaghy, Dillon, Gibbins, Jonathan M.
Publicado en Platelets (2018)

RXR Ligands Negatively Regulate Thrombosis and Hemostasis

por Unsworth, Amanda J., Flora, Gagan D., Sasikumar, Parvathy, Bye, Alexander P., Sage, Tanya, Kriek, Neline, Crescente, Marilena, Gibbins, Jonathan M.
Publicado en Arterioscler Thromb Vasc Biol (2017)

The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects

por Stainer, Alexander R., Sasikumar, Parvathy, Bye, Alexander P., Unsworth, Amanda J., Holbrook, Lisa M., Tindall, Marcus, Lovegrove, Julie A., Gibbins, Jonathan M.
Publicado en TH Open (2019)

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

por Gaspar, Renato S., Unsworth, Amanda J., Al-Dibouni, Alaa, Bye, Alexander P., Sage, Tanya, Stewart, Michelle, Wells, Sara, Cox, Roger D., Gibbins, Jonathan M., Sellayah, Dyan, E. Hughes, Craig
Publicado en Sci Rep (2021)

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib

por Bye, Alexander P., Unsworth, Amanda J., Desborough, Michael J., Hildyard, Catherine A. T., Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H., Sage, Tanya, Hughes, Craig E., Gibbins, Jonathan M.
Publicado en Blood Adv (2017)

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets

por Unsworth, Amanda J., Bye, Alexander P., Tannetta, Dionne S., Desborough, Michael J.R., Kriek, Neline, Sage, Tanya, Allan, Harriet E., Crescente, Marilena, Yaqoob, Parveen, Warner, Timothy D., Jones, Chris I., Gibbins, Jonathan M.
Publicado en Arterioscler Thromb Vasc Biol (2017)

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

por Unsworth, Amanda J., Bye, Alexander P., Sage, Tanya, Gaspar, Renato S., Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J., Hutchinson, James L., Riley, Ryan, Jones, Sarah, Mundell, Stuart J., Cui, Weiguo, Falet, Hervé, Gibbins, Jonathan M.
Publicado en Haematologica (2020)

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets

por Bye, Alexander P., Hoepel, Willianne, Mitchell, Joanne L., Jégouic, Sophie, Loureiro, Silvia, Sage, Tanya, Vidarsson, Gestur, Nouta, Jan, Wuhrer, Manfred, de Taeye, Steven, van Gils, Marit, Kriek, Neline, Cooper, Nichola, Jones, Ian, den Dunnen, Jeroen, Gibbins, Jonathan M.
Publicado en Blood (2021)

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation

por Dunster, Joanne L., Unsworth, Amanda J., Bye, Alexander P., Haining, Elizabeth J., Sowa, Marcin A., Di, Ying, Sage, Tanya, Pallini, Chiara, Pike, Jeremy A., Hardy, Alexander T., Nieswandt, Bernhard, García, Ángel, Watson, Steve P., Poulter, Natalie S., Gibbins, Jonathan M., Pollitt, Alice Y.
Publicado en J Thromb Haemost (2019)

Gap Junctions and Connexin Hemichannels Underpin Haemostasis and Thrombosis

por Vaiyapuri, Sakthivel, Jones, Chris I., Sasikumar, Parvathy, Moraes, Leonardo A., Munger, Stephanie J., Wright, Joy R., Ali, Marfoua S., Sage, Tanya, Kaiser, William J., Tucker, Katherine L., Stain, Christopher J., Bye, Alexander P., Jones, Sarah, Oviedo-Orta, Ernesto, Simon, Alexander M., Mahaut-Smith, Martyn P., Gibbins, Jonathan M.
Publicado 2012

Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets

por Sahli, Khaled A., Flora, Gagan D., Sasikumar, Parvathy, Maghrabi, Ali H., Holbrook, Lisa-Marie, AlOuda, Sarah K., Elgheznawy, Amro, Sage, Tanya, Stainer, Alexander R., Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vaiyapuri, Sakthivel, Bye, Alexander P., Unsworth, Amanda J., Jones, Chris I., McGuffin, Liam J., Gibbins, Jonathan M.
Publicado en Blood (2021)