Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis

The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects. Since platelets contribute towards the development of...

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Vydáno v:Sci Rep
Hlavní autoři: Flora, Gagan D., Sahli, Khaled A., Sasikumar, Parvathy, Holbrook, Lisa-Marie, Stainer, Alexander R., AlOuda, Sarah K., Crescente, Marilena, Sage, Tanya, Unsworth, Amanda J., Gibbins, Jonathan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868193/
https://ncbi.nlm.nih.gov/pubmed/31748641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53218-x
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