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A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis
ESSENTIALS: ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti‐ERp72). Anti‐ERp72 inhibits platelet functional responses and thrombosis. SUMMARY: BACKGROUND...
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| Publicat a: | J Thromb Haemost |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5838528/ https://ncbi.nlm.nih.gov/pubmed/29052936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13878 |
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