A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis

ESSENTIALS: ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti‐ERp72). Anti‐ERp72 inhibits platelet functional responses and thrombosis. SUMMARY: BACKGROUND...

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Publié dans:J Thromb Haemost
Auteurs principaux: Holbrook, L.‐M., Sandhar, G. K., Sasikumar, P., Schenk, M. P., Stainer, A. R., Sahli, K. A., Flora, G. D., Bicknell, A. B., Gibbins, J. M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838528/
https://ncbi.nlm.nih.gov/pubmed/29052936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13878
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