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Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial indel formation) and homology-directed repair (which typically leads to low editing efficiency). Here, we show, in adult...
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| Publicat a: | Nat Biomed Eng |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7885272/ https://ncbi.nlm.nih.gov/pubmed/33077938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-00632-6 |
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