Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial indel formation) and homology-directed repair (which typically leads to low editing efficiency). Here, we show, in adult...

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Veröffentlicht in:Nat Biomed Eng
Hauptverfasser: Suh, Susie, Choi, Elliot H., Leinonen, Henri, Foik, Andrzej T., Newby, Gregory A., Yeh, Wei-Hsi, Dong, Zhiqian, Kiser, Philip D., Lyon, David C., Liu, David R., Palczewski, Krzysztof
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885272/
https://ncbi.nlm.nih.gov/pubmed/33077938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-00632-6
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