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Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65

RPE65 is the essential trans–cis isomerase of the classical retinoid (visual) cycle. Mutations in RPE65 give rise to severe retinal dystrophies, most of which are associated with loss of protein function and recessive inheritance. The only known exception is a c.1430G>A (D477G) mutation that give...

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Choi, Elliot H, Suh, Susie, Sander, Christopher L, Hernandez, Christian J Ortiz, Bulman, Elizabeth R, Khadka, Nimesh, Dong, Zhiqian, Shi, Wuxian, Palczewski, Krzysztof, Kiser, Philip D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005012/
https://ncbi.nlm.nih.gov/pubmed/29659842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy128
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