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Dendritic cell-derived TGF-β mediates the induction of mucosal regulatory T cell response to Helicobacter infection essential for maintenance of immune tolerance in mice

BACKGROUND: Helicobacter pylori infection leads to regulatory T-cell (Treg) induction in infected mice, which contributes to H. pylori immune escape. However, the mechanisms responsible for H. pylori induction of Treg and immune tolerance remain unclear. We hypothesized DC-produced TGF-β may be resp...

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Detalhes bibliográficos
Publicado no:Helicobacter
Main Authors: Owyang, Stephanie Y., Zhang, Min, El-Zaatari, Mohamad, Eaton, Kathryn A., Bishu, Shrinivas, Hou, Guoqing, Grasberger, Helmut, Kao, John Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885176/
https://ncbi.nlm.nih.gov/pubmed/33025641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hel.12763
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