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Increased Expression of DUOX2 is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

BACKGROUND & AIMS: Dual oxidase 2 (DUOX2), a hydrogen-peroxide generator at the apical membrane of gastrointestinal epithelia, is upregulated in patients with inflammatory bowel disease (IBD) before the onset of inflammation, but little is known about its effects. We investigated the role of DUO...

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Bibliografske podrobnosti
izdano v:	Gastroenterology
Main Authors:	Grasberger, Helmut, Gao, Jun, Nagao-Kitamoto, Hiroko, Kitamoto, Sho, Zhang, Min, Kamada, Nobuhiko, Eaton, Kathryn A., El-Zaatari, Mohamad, Shreiner, Andrew B., Merchant, Juanita L., Owyang, Chung, Kao, John Y.
Format:	Artigo
Jezik:	Inglês
Izdano:	2015
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4663159/ https://ncbi.nlm.nih.gov/pubmed/26261005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.07.062
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Increased Expression of DUOX2 is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

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