Increased Expression of DUOX2 is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine

BACKGROUND & AIMS: Dual oxidase 2 (DUOX2), a hydrogen-peroxide generator at the apical membrane of gastrointestinal epithelia, is upregulated in patients with inflammatory bowel disease (IBD) before the onset of inflammation, but little is known about its effects. We investigated the role of DUO...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Grasberger, Helmut, Gao, Jun, Nagao-Kitamoto, Hiroko, Kitamoto, Sho, Zhang, Min, Kamada, Nobuhiko, Eaton, Kathryn A., El-Zaatari, Mohamad, Shreiner, Andrew B., Merchant, Juanita L., Owyang, Chung, Kao, John Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663159/
https://ncbi.nlm.nih.gov/pubmed/26261005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.07.062
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