ΦX174 Attenuation by Whole-Genome Codon Deoptimization

Natural selection acting on synonymous mutations in protein-coding genes influences genome composition and evolution. In viruses, introducing synonymous mutations in genes encoding structural proteins can drastically reduce viral growth, providing a means to generate potent, live-attenuated vaccine...

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Dades bibliogràfiques
Publicat a:Genome Biol Evol
Autors principals: Van Leuven, James T, Ederer, Martina M, Burleigh, Katelyn, Scott, LuAnn, Hughes, Randall A, Codrea, Vlad, Ellington, Andrew D, Wichman, Holly A, Miller, Craig R
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881332/
https://ncbi.nlm.nih.gov/pubmed/33045052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evaa214
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