Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory-tract disease worldwide. A vaccine or generally effective antiviral drug is not yet available. We designed new live attenuated RSV vaccine candidates by codon-pair deoptimization (CPD). Specifi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Le Nouën, Cyril, Brock, Linda G., Luongo, Cindy, McCarty, Thomas, Yang, Lijuan, Mehedi, Masfique, Wimmer, Eckard, Mueller, Steffen, Collins, Peter L., Buchholz, Ursula J., DiNapoli, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246931/
https://ncbi.nlm.nih.gov/pubmed/25157129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411290111
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