Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

Ítems similars

• Rescue of codon-pair deoptimized respiratory syncytial virus by the emergence of genomes with very large internal deletions that complemented replication
  per: Le Nouën, Cyril, et al.
  Publicat: (2021)
• Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity
  per: Le Nouën, Cyril, et al.
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• Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure
  per: Le Nouën, Cyril, et al.
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• Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters.
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• Reduction of the Rate of Poliovirus Protein Synthesis through Large-Scale Codon Deoptimization Causes Attenuation of Viral Virulence by Lowering Specific Infectivity
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