A carregar...

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Le Nouën, Cyril, McCarty, Thomas, Brown, Michael, Smith, Melissa Laird, Lleras, Roberto, Dolan, Michael A., Mehedi, Masfique, Yang, Lijuan, Luongo, Cindy, Liang, Bo, Munir, Shirin, DiNapoli, Joshua M., Mueller, Steffen, Wimmer, Eckard, Collins, Peter L., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255620/
https://ncbi.nlm.nih.gov/pubmed/28049853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619242114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!