Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Le Nouën, Cyril, McCarty, Thomas, Brown, Michael, Smith, Melissa Laird, Lleras, Roberto, Dolan, Michael A., Mehedi, Masfique, Yang, Lijuan, Luongo, Cindy, Liang, Bo, Munir, Shirin, DiNapoli, Joshua M., Mueller, Steffen, Wimmer, Eckard, Collins, Peter L., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255620/
https://ncbi.nlm.nih.gov/pubmed/28049853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619242114
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