Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Le Nouën, Cyril, McCarty, Thomas, Brown, Michael, Smith, Melissa Laird, Lleras, Roberto, Dolan, Michael A., Mehedi, Masfique, Yang, Lijuan, Luongo, Cindy, Liang, Bo, Munir, Shirin, DiNapoli, Joshua M., Mueller, Steffen, Wimmer, Eckard, Collins, Peter L., Buchholz, Ursula J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255620/
https://ncbi.nlm.nih.gov/pubmed/28049853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619242114
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