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Reduced Protein Expression in a Virus Attenuated by Codon Deoptimization
A general means of viral attenuation involves the extensive recoding of synonymous codons in the viral genome. The mechanistic underpinnings of this approach remain unclear, however. Using quantitative proteomics and RNA sequencing, we explore the molecular basis of attenuation in a strain of bacter...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | G3 (Bethesda) |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Genetics Society of America
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5592923/ https://ncbi.nlm.nih.gov/pubmed/28698233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.041020 |
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