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Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
The dysregulation of gene dosage due to duplication or haploinsufficiency is a major cause of autosomal dominant diseases such as Alzheimer’s disease. However, there is currently no rapid and efficient method for manipulating gene dosage in a human model system such as human induced pluripotent stem...
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| 出版年: | Commun Biol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7881037/ https://ncbi.nlm.nih.gov/pubmed/33580208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01722-0 |
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