CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells (iPSCs)...

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Bibliografiske detaljer
Udgivet i:Protein Cell
Main Authors: Wang, Lixia, Yi, Fei, Fu, Lina, Yang, Jiping, Wang, Si, Wang, Zhaoxia, Suzuki, Keiichiro, Sun, Liang, Xu, Xiuling, Yu, Yang, Qiao, Jie, Belmonte, Juan Carlos Izpisua, Yang, Ze, Yuan, Yun, Qu, Jing, Liu, Guang-Hui
Format: Artigo
Sprog:Inglês
Udgivet: Higher Education Press 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413600/
https://ncbi.nlm.nih.gov/pubmed/28401346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-017-0397-3
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