Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Xeroderma pigmentosum (XP) is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of DNA repair. XP patients frequently exhibit neurological degeneration, but the underlying mechanism is unknown, in part due to lack of proper disease models. Here, we gene...

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Gepubliceerd in:Protein Cell
Hoofdauteurs: Fu, Lina, Xu, Xiuling, Ren, Ruotong, Wu, Jun, Zhang, Weiqi, Yang, Jiping, Ren, Xiaoqing, Wang, Si, Zhao, Yang, Sun, Liang, Yu, Yang, Wang, Zhaoxia, Yang, Ze, Yuan, Yun, Qiao, Jie, Belmonte, Juan Carlos Izpisua, Qu, Jing, Liu, Guang-Hui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Higher Education Press 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791426/
https://ncbi.nlm.nih.gov/pubmed/26874523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0244-y
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