Efficient gene correction of an aberrant splice site in β‐thalassaemia iPSCs by CRISPR/Cas9 and single‐strand oligodeoxynucleotides

β‐thalassaemia is a prevalent hereditary haematological disease caused by mutations in the human haemoglobin β (HBB) gene. Among them, the HBB IVS2‐654 (C > T) mutation, which is in the intron, creates an aberrant splicing site. Bone marrow transplantation for curing β‐thalassaemia is limited due...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Cell Mol Med
Asıl Yazarlar: Xiong, Zeyu, Xie, Yingjun, Yang, Yi, Xue, Yanting, Wang, Ding, Lin, Shouheng, Chen, Diyu, Lu, Dian, He, Lina, Song, Bing, Yang, Yinghong, Sun, Xiaofang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850948/
https://ncbi.nlm.nih.gov/pubmed/31631510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14669
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller