Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation. Ornithine decarboxyla...

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Publicat a:Nat Commun
Autors principals: Khan, Aaminah, Gamble, Laura D., Upton, Dannielle H., Ung, Caitlin, Yu, Denise M. T., Ehteda, Anahid, Pandher, Ruby, Mayoh, Chelsea, Hébert, Steven, Jabado, Nada, Kleinman, Claudia L., Burns, Mark R., Norris, Murray D., Haber, Michelle, Tsoli, Maria, Ziegler, David S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881014/
https://ncbi.nlm.nih.gov/pubmed/33579942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20896-z
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