DIPG-16. COMBINATION OF ARGININE DEPLETION AND POLYAMINE INHIBITION AS AN ANTICANCER STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

DIPG is an aggressive pediatric brainstem tumor, with a median survival below 12 months. Tumor cells are dependent upon arginine, a semi-essential amino acid, metabolised by arginase enzymes into ornithine, a pivotal precursor to the polyamine pathway. Polyamines, frequently upregulated in cancer, a...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Khan, Aaminah, Gamble, Laura, Pandher, Ruby, Burns, Mark R, Mussai, Francis, Norris, Murray, Haber, Michelle, Tsoli, Maria, Ziegler, David S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715139/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.066
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