DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity against DIPG neurospheres. CBL01...

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Vydáno v:Neuro Oncol
Hlavní autoři: Ehteda, Anahid, Franshaw, Laura, Liu, Jie, Joshi, Swapna, Simon, Sandy, Pang, Chi Nam Ignatius, Giorgi, Federico, Pandher, Ruby, Ung, Caitlin, Tolhurst, Ornella, Mayoh, Chelsea, Khan, Aaminah, Hayden, Elisha, Gopalakrishnan, Anjana, Trebilcock, Peter, Upton, Dannielle, Lehmann, Rebecca, George, Sandra, Vittorio, Orazio, Tsoli, Maria, Gurova, Katerina, Gudkov, Andrei Gudkov, Norris, Murray D, Haber, Michelle, Ziegler, David S
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Diffuse Midline Glioma/DIPG
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715505/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.076
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