HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG

DIPG is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity against DIPG neurospheres. CBL0137, a compound modelled on quinacri...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M, Liu, Jie, Hayden, Elisha, Rouaen, Jourdin, Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Kankean, Anne, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei, Norris, Murray D, Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
High Grade Gliomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168074/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.075
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