ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

The response to Poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impacts viability in these se...

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發表在:Nat Cell Biol
Main Authors: Verma, Priyanka, Zhou, Yeqiao, Cao, Zhendong, Deraska, Peter V., Deb, Moniher, Arai, Eri, Li, Weihua, Shao, Yue, Puentes, Laura, Li, Yiwen, Patankar, Sonali, Mach, Robert H., Faryabi, Robert B., Shi, Junwei, Greenberg, Roger A.
格式: Artigo
語言:Inglês
出版: 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880902/
https://ncbi.nlm.nih.gov/pubmed/33462394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-00624-3
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